The Cosmic Deities are deities whose spacial domain consists of the entire NeSiverse, rather than being bound to a specific planet, culture or group of followers. One of these deities can actually be replaced by another should that deity be destroyed, as with Runekeeper being replaced by Hermes Trismegistus upon the original Runekeeper's demise. These deities are often bickering amongst themselves and they were all once locked out of Earth by the Ancient One and upon regaining influence there, they were again banned by the domain on laws set by Ma'at. Many of them served the 12 God-Monarchs before they were destroyed or time-locked.

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